Custom Peptides
Cayman Chemical R S-3 5-DHPG 10mg
An agonist of group I mGluRs; induces phosphoinositol hydrolysis in MCB3901 cells expressing human mGluR1a and mGluR5a; potentiates NMDA-induced depolarizations in rat hippocampal slices at 10 µM; intrathecal administration increases mean blood pressure in anesthetized rats at 300 nmol/animal; induces seizures in rats at 1.5 µmol/animal, i.c.v.
Cayman Chemical LnInamIvIr octnoate 10mg
An inhibitor of influenza neuraminidases and a prodrug form of laninamivir; selectively inhibits the neuraminidases from influenza A H1N1, H2N2, and H3N2 strains (mean IC50s = 822, 128, and 114 nM, respectively) over the neuraminidases from influenza B Victoria and Yamagata strains (mean IC50s = >10,000 nM for both); increases survival in a mouse model of lethal influenza H1N1 infection when administered intranasally at 0.95 UG/kg
Cayman Chemical FosInoprIlsodIum salt 10mg
A prodrug form of fosinoprilat; inhibits angiotensin I-induced pressor responses in normotensive rats, dogs, and monkeys at 15, 15, and 10 µmol/kg, respectively; reduces fractional shortening and decreases left ventricular size in a porcine model of congestive heart failure at 2.5 mg/kg
Cayman Chemical Xylotetraose 10mg
A xylooligosaccharide; has been found in corn and various plant-based agricultural wastes
Cayman Chemical EcabetsodIum salt 10mg
An antiulcerative and gastroprotective agent; reduces the viability of H. pylori grown under urea-supplemented acidic conditions in a concentration-dependent manner; inhibits H. pylori urease activity in a pH-dependent manner (IC50s = 2.1-2.6 and >16 mg/ml at pH values of 5 and 8, respectively); inhibits adhesion of H. pylori to MKN-28 cells at 1 and 2 mg/ml; increases levels of PGE2 in rat gastric mucosa at 25 and 100 mg/kg, p.o. in vivo; inhibits formation of hemorrhagic lesions in esophageal mucosa and reduces gastric juice pepsin activity in a rat model of reflux induced by fore-stomach and pyloric ligation at 30 mg/kg
Cayman Chemical n3365hydrochlorIde 10mg
A LeuRS inhibitor (IC50 = 0.31 µM for the E. coli enzyme); active against a variety of bacteria, including MDR clinical isolates (MICs = 2-8 UG/ml); inhibits protein, RNA, DNA, and fatty acid synthesis in E. coli (IC50s = 8.3, 105, 366, and 396 UG/ml, respectively); reduces the number of CFUs in neutropenic mouse thigh models of E. coli or P. aeruginosa infection at 30 mg/kg
Cayman Chemical Narcs poetcus Lycorn 10mg
An alkaloid with diverse biological activities; active against P. falciparum (IC50 = 1.026 UG/ml); inhibits SARS-CoV viral infection in Vero cells (EC50 = 15.7 µM); inhibits migration of A549 NSCLC and U373 MG glioblastoma cells at 5 µM; increases survival and reduces virus-induced paralysis in a mouse model of enterovirus 71 infection at 0.4 mg/kg
Cayman Chemical KevetrInhydrochlorIde 10mg
An activator of p53; increases levels of activated p53 and expression of p21 in A549 cells and decreases expression of the transcription factor E2F1 in a variety of cell lines; decreases cell viability in a panel of cancer cell lines (mean IC50 = 0.49 μM); reduces tumor growth in various mouse xenograft models at 200 mg/kg
Cayman Chemical PPAdodIum salt 10mg
A non-selective P2 purinergic antagonist that blocks recombinant P2X1-5 (IC50s = 1-2.6 μM), native P2Y2-like (IC50 = ~0.9 mM), and recombinant P2Y4 (IC50 = ~15 mM) receptors; produces neuroprotective effects in an ischemia model with permanent middle cerebral artery occlusion in spontaneously hypertensive rats
Cayman Chemical trcetrapb 10mg
A CETP inhibitor (IC50s = 47 and 51 nM for cholesteryl and triglyceride transfer, respectively); selective for CETP over PLTP, LCAT, and hepatic and lipoprotein lipases at 10 µM; inhibits CETP activity and increases HDL cholesterol levels in serum from transgenic mice expressing human CETP and ApoA1 at 30 mg/kg; increases mean arterial blood pressure in Zucker fa/fa diabetic rats at 60 and 200 mg/kg
Cayman Chemical 5 Z 8 Z 11 ZEIcosatrIenoI 10mg
A prolyl endopeptidase inhibitor (Kis 0.35 and 0.5 nM for the mouse and human enzymes respectively) inhibits the formation of angiotensin (1-7) from angiotensin II in kidney sections isolated from wild-type and Ace2-/- mice at 4 and 40 UM reduces hippocampal neuronal cell death in a rat model of global ischemia at 10 and 50 mg/kg
Cayman Chemical N 4AmInophenylmethyladen 10mg
An adenosine derivative; has been used as an intermediate in the synthesis of [125I]-N6-4-aminobenzyladenosine